Syrspend SF | 2016 Compatibility of Cholecalciferol, Haloperidol, Imipramine Hydrochloride, Levodopa/Carbidopa, Lorazepam, Minocycline Hydrochloride, Tacrolimus Monohydrate, Terbinafine, Tramadol Hydrochloride and Valsartan in SyrSpend® SF PH4 oral suspensions. Polonini HC, Silva SL, Cunha CN, Brandao MAF, Ferreira AO Pharmazie, 71(4), pages 185-191 The objective of this study was to evaluate the compatibility of 10 APIs in SyrSpend® SF PH4. The beyond-use date was 90 days for most suspensions both refrigerated and RT. Exceptions: Minocycline hydrochloride at both storage temperatures (60 days), levodopa/carbidopa at RT (30 days), and lorazepam at RT (60 days). Read more SEE PRODUCT
Pentravan | 2016 Evaluation of Pentravan®, Pentravan® Plus, Phytobase®, Lipovan® and Pluronic Lecithin Organogel for the transdermal administration of antiemetic drugs to treat chemotherapy-induced nausea and vomiting at the hospital. Bourdon F, Lecoeur M, Leconte L, Ultre V, Kouach M, Odou P, Vaccher C, Foulon C International Journal of Pharmaceutics, 515(1-2), 774-787 The objective was to evaluate five transdermal vehicles for the compounding of ondansetron, dexamethasone, and aprepitant. Diffusion experiments showed that the release and permeation process were greater for ondansetron than for dexamethasone and aprepitant. When ondansetron and dexamethasone were compounded in combination in Pentravan® Plus, a permeation decrease was observed. Read more SEE PRODUCT
Pentravan | 2016 Ex-vivo permeation of Enrofloxacin through shed skin of Python molurus bivittatus, as evaluated with a Franz cell. Ducrotte-Tassel A, Kirilov P, Salvi JP, Hung Tran V, Dore V, Marignac G, Pignon CP, Perrot S, Boulieu R Journal of Drug Delivery Science and Technology, 36, 89-94 In this study, the in vitro permeation of an antibiotic, enrofloxacin, administered percutaneously to the shed skin of Python molurus bivittatus was analyzed. Results confirmed that enrofloxacin can be absorbed through the shed skin of snakes and investigated the percutaneous route as a new option for administering drugs when treating snakes. Read more SEE PRODUCT
Pentravan | 2016 Effect of vaginal gestrinone in Pentravan® on endometriosis patients using Mirena®: A preliminary report Maia H jr, Haddad C, dos Santos Junior WSD, Pinheiro N, Hirsch MC, Silva Santo A Clinical Obstetrics, Gynecology and Reproductive Medicine, 2(2), 157-160 The objective was to investigate the effect of low doses of vaginal gestrinone with oral Pinus pinaster extract and resveratrol on endometriosis-related pain. Results showed that concomitant use of Mirena® with low doses of vaginal gestrinone in association with oral antioxidants is an effective treatment for deep endometriosis-related pain. Read more SEE PRODUCT
Pentravan | 2015 Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases. Polonini HC, Soldati PP, Aparecida de Almeida P, Azevedo da Silva CG, Hollingworth Collins C, Leal de Oliveira MA, de Oliveira Ferreira A, Raposo NRB, Brandao MAF Journal of Chromatography B, 1002, 8-12 The study purposed to evaluate the trans-resveratrol permeation efficacy through the vaginal route. The permeation experiments showed that resveratrol, in the formulation used, was not successfully delivered to the bloodstream – it was actually retained within the vaginal mucosa, which suggests a local use rather a systemic one. Read more SEE PRODUCT
Syrspend SF | 2015 Stability assessment of 10 active pharmaceutical ingredients compounded in SyrSpend® SF Geiger CM, Sorenson B, Whaley P International Journal of Pharmaceutical Compounding, 19(5), 420-427 The stability of 10 active pharmaceutical ingredients was studied in SyrSpend® SF PH4 or SyrSpend SF Alka. This study demonstrated the stability of a wide range of frequently used active pharmaceutical ingredients, tested in SyrSpend SF PH4 and SyrSpend® SF Alka at different storage conditions. Read more SEE PRODUCT
Pentravan | 2015 Studies with emulsion containing trans-resveratrol: In Vitro release profile and Ex Vivo human skin permeation Aparecida de Almeida P, Campos Alves M, Polonini HC, Lima Calixto S, Brum Braga Gomes T, Augusto Barros Lataliza A, Dias da Silveira Ramos C, Raposo NRB, de Oliveira Ferreira A, Brandao MAF Current Drug Delivery, 12(2), 157-165 An analytical method by HPLC was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The results suggest that the emulsion studied is a potential vehicle for trans-resveratrol administration by transdermal route. Read more SEE PRODUCT
Fitalite | 2014 Green tea in transdermal formulation: HPLC method for quality control and In Vitro drug release assays Campos Alves M, Aparecida de Almeida P, Polonini HC, Raposo NRB, de Oliveira Ferreira A, Brandao MAF Quimica Nova, 37(4), 728-735 RP-HPLC based analytical method for use in both quality control of green tea in a semisolid formulation and for in vitro drug release assays was developed and validated. The data showed that EGCG will be able to exert its systemic activity when delivered though the transdermal formulation. Read more SEE PRODUCT
Pentravan | 2014 Transdermal formulations containing human sexual steroids: Development and validation of methods and In Vitro drug release Polonini HC, Soldati PP, Leal de Oliveira MA, Brandao MAF, Chaves MGM, Raposo NRB Quimica Nova, 37(4), 720-727 In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. The emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids Read more SEE PRODUCT
Pentravan | 2014 Evaluation of percutaneous absorption performance for human female sexual steroids into Pentravan® Cream Polonini HC, Brandao MAF, Ferreira AO, Ramos C, Raposo NRB International Journal of Pharmaceutical Compounding, 18(4), 332-340 The purpose of this study was to evaluate the permeation potential of Pentravan. According to the results, human female sexual hormones incorporated in the oil-in-water vanishing cream base and applied topically are expected to exert their biological activities systemically with good efficacy due to their satisfactory permeation through human skin. Read more SEE PRODUCT