Syrspend SF | 2020 Stability of Azathioprine, Clonidine Hydrochloride, Clopidogrel Bisulfate, Ethambutol Hydrochloride, Griseofulvin, Hydralazine Hydrochloride, Nitrofurantoin, and Thioguanine oral suspensions compounded with SyrSpend® SF pH4 Polonini HC, Loures da Silva S, Neves Cunha C, Ferreira AO, Anagnostou K, Dijkers E International Journal of Pharmaceutical Compounding, 24(3), 252-262 The objective of this study was to evaluate the stability of oral suspensions compounded with SyrSpend SF PH4 and commonly used active pharmaceutical ingredients (APIs). Formulations using the API in powder form presented a higher beyond-use date, and SyrSpend SF PH4 shows suitability for compounding APIs from different pharmacological classes. Read more SEE PRODUCT
Syrspend SF | 2020 Always the right dose? Content uniformity in over 100 different formulations tested Dijkers E, Polonini HC, Ferreira AO International Journal of Pharmaceutical Compounding, 24 (5), 408-412 Analyses with SyrSpend SF in 104 different formulations with 89 unique active pharmaceutical ingredients showed results that all 6.414 samples analyzed were within specification. The results suggest that SyrSpend SF could be a better way to assure content uniformity compared to manually compounded, small-batch extemporaneous capsules. Read more SEE PRODUCT
Trichoxidil | 2020 Hair growth promoting effect of Trichoxidil™: A new natural compound for hair loss Labinas G, Amaral F, de Souza Antunas VM, Jardim M, Mendes Bella L, Rocha Oliveira C Journal of Cosmetics, Dermatological Sciences and Applications, 10(4), 176 The study aimed to investigate the effect of Trichoxidil in the treatment of hair loss caused by androgenetic alopecia (AGA). Trichoxidil promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA. Read more SEE PRODUCT
Pinetonina | 2020 Intranasal use of lavender and fennel decreases salivary cortisol levels and improves quality of sleep: A double-blind randomized clinical trial Polonini HC, Mesquita D, Lanine J, Dijkers E, Gkinis S, Raposo NRB, Ferreira AO European Journal of Integrative Medicine, 34, 101015 The current study investigates the effect of intranasal administration of essential oils obtained from lavender, French lavender, and fennel (Pinetonina™), on chronic stress. Daily intranasal use of Pinetonina™ before sleep showed a significant reduction of salivary cortisol levels and improved quality of sleep. Read more
Miodesin | 2020 Anti-inflammatory activity of Miodesin™: Modulation of inflammatory markers and epigenetic evidence Rocha Oliveira C, Paula Vieira R Oxidative Medicine and Cellular Longevity, 2020 This research investigated the effects of Miodesin™ on acute and chronic inflammatory processes as well as possible epigenetic involvement. Miodesin™ inhibited the release of LPS-induced cytokines and chemokines, and the expression of the transcription factor, inflammatory enzymes, and chemokines. In addition, Miodesin™ did not induce changes in DNA methylation. Read more
FagronLab | 2020 Efficacy of an automated robotic cleaning device for compounding pharmacies Polonini HC, Dijkers E, Ferreira AO, da Silva SL, Araujo PVC, Koulouridas S International Journal of Pharmaceutical Compounding, 24(5), 426-433 The study evaluated the efficacy of an automated robotic cleaning device (RVC1) for compounding pharmacies and other primary healthcare establishments. RVC1 showed the necessary microbiological and chemical efficacy to be used in the cleaning routine of compounding pharmacies, both in a single-step cleaning or in a double-step cleaning. Read more
CitrusiM | 2019 A randomized trial on the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition Kegele CS, Oliveira J, Magrani T, Ferreira A, de Souza Ferreira R, Sabbaghi A, Ferreira AO, Brandao MAF, Raposo NRB, Polonini HC Clinical Nutrition Experimental, 27, 29-36 This study investigated the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition, defined in terms of two outcomes: percentage of lean mass and percentage of fat mass. There was a statistically significant evidence that the treatment may increase lean mass and reduce fat mass. Read more
FagronLab | 2019 Towards the importance of a Roller Mill in compounding practice: An experimental approach Polonini HC, Loures da Silva S, Batista PF, Brandao MAF, Ferreira AO International Journal of Pharmaceutical Compounding, 23(2), 154-156 In this paper, the use of an ointment mill in final steps of compounding semisolid dosage forms is evaluated, showing better homogeneity when assessing content uniformity of progesterone 5%, estradiol 0.1%, and estriol 0.4% creams. Finally, the proposed cleaning procedure decreased the presence of compounded preparation to a “none-detection” level. Read more
Pentravan | 2019 Ex Vivo evaluation of intravaginal Progesterone and Testosterone to treat the luteal-phase deficiency and vaginal atrophy Laque LC, Raposo NRB, Brandao MAF, Ferreira AO, Polonini HC International Journal of Pharmaceutical Compounding, 23 (1), 77-81 The purpose of this study was to evaluate the transmucosal permeation of progesterone and testosterone using Pentravan as its vehicle for vaginal delivery. The permeation studies revealed that testosterone formulated with Pentravan is potentially effective in reaching the bloodstream and acts locally, whereas progesterone was mostly retained in the mucosa. Read more SEE PRODUCT
Pentravan | 2019 Topical Monomethylsilanetriol can deliver silicon to the viable skin Polonini HC, Ferreira AO, Brandao MAF, Raposo NRB International Journal of Cosmetic Science, 41(4), 405-409 The main objective of the study was to assess whether SiliciuMax (liquid) can deliver silicon to the epidermis and dermis, when applied topically in a cream. Evidence shows that SiliciuMax applied topically can deliver silicon to the skin in biorelevant levels for cosmetic purposes. Read more SEE PRODUCT