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Bioidentical hormone replacement therapy in gynecology

Personalized medicine 4 min read

Menopause and hormone imbalance

Not all women struggle with hormonal issues, but many experience their share of hormonal ups and downs. Loss of libido, vaginal dryness, mood swings, loss of muscle mass, insomnia, hot flushes, and night sweats are all symptoms of hormonal imbalances.
Hormone imbalance is a common side effect of the aging process and menopause. Along with a healthy diet, exercise, and nutrition, supplementation with bioidentical hormones can help to restore hormonal balance within a woman’s body, providing relief from symptoms associated with the variations. They can significantly improve health, wellness, and quality of life.
Fagron has developed innovative, effective, and safe treatment options to treat women during all stages of life.

What is Bioidentical Hormone Replacement Therapy?

Hormones are an important part of your body’s messenger system. These chemicals send signals to almost every part of your body. They control things like your mood, growth, and even body hair. It’s difficult for you to function properly when your hormones are unbalanced.

The expression “bioidentical hormones” often refers to hormones that, despite being obtained through organic synthesis as a primer substrate (then, they are synthetic), possess a chemical structure identical to human endogenous sexual hormones. They’re designed so your body uses them in the same way it does your own hormones.

Hormone therapy with Fagron solutions

It is important to choose a highly effective, completely safe, and most suitable transdermal permeation promoter vehicle for each application.
Thanks to pharmaceutical research, Fagron offers an innovative proposal of personalized medicine composed of bioidentical hormones in Pentravan® and HUMCO (a Fagron Group company) bases, HRT Heavy™ and HRT Botanical™, providing an ideal hormonal profile with high efficiency and safety.

  • Pentravan® is a liposomal matrix vehicle ideal for applying sex hormones at the vaginal and vestibule-vulvar levels, as it consists of an oil-in-water emulsion capable of establishing a greater rate and extent of absorption the API than other transdermal bases.
    It is ready-to-use to facilitate compounding by the pharmacist. Therefore, more of the API will become available in a shorter time to establish the effect of the therapy.
  • Pentravan® is free of petrolatum, petroleum jelly, propylene glycol, parabens and allows the hydration of the mucous membrane thanks to plant liposomes and pH 4-5.5.
  • HRT Heavy™ is an oil-based cream in water with an excellent penetration capacity and is ideal for applying hormones to the body. It has a protective and moisturizing texture, an excellent transdermal penetration profile, and allows the formulation of lipophilic and hydrophilic active ingredients up to a concentration of 20%. It is specifically designed for male and female hormone restoration formulations and has moderate to high API carrying capacity. It is suitable for topical or intravaginal preparations.
  • HRT Heavy™ is free of perfumes, dyes, parabens, petroleum jelly, petrolatum oil, SLS, and propylene glycol, and contains a mixture of mild preservatives.
  • HRT Botanical™ is an ideal cream for applying hormones to the body, face, and neckline. It consists of a fluid formulation rich in vegetable ingredients with high moisturizing power and presents an innovative transdermal penetration technology.
  • HRT Botanical™ is Paraben¬-free & fragrance¬-free, made with natural ingredients and natural preservatives

Personalized treatment

Hormone replacement therapy can be personalized to meet the specific treatment needs of the patients. With standardized dosages, you may be forced to choose between a slightly too high dose that produces unwanted side effects or a too low dose that doesn’t provide adequate symptom relief. Customization allows each patient to receive treatment according to their individual hormone balance and symptoms, improving efficacy and tolerability.

Also, custom hormone medications can be produced in various formats, including pills, patches, creams, gels, injections, and pellets, allowing the patient to choose a preparation that works for their preferences and lifestyle.