Sabine has dehydrated skin and struggles with hyperpigmentation.

Case study | 18 Jul 2024


Hyperpigmentation occurs when melanin is overproduced in certain areas of the skin. Hyperpigmentation results in flat, dark spots on the skin that are light brown to black in color and can vary in size and shape. Pigment spots such as age spots are caused by sun exposure. For this reason, they occur mainly on parts of the body that are frequently exposed, such as the face, hands, and arms. They are usually small, dark spots on the skin.

Sabine experiences a dehydrated skin

Sabine, a 40-year old patient is struggling with hyperpigmentation. Her skin looked pretty good for her age, with a few wrinkles, pores are nice and fine and her skin is quite tight, but she suffers from hyperpigmentation. On a number of places on her face (cheeks, eyebrows, and forehead) she had very dark discoloration which, no matter how hard she tried, would not go away, even with good skincare. “And that bothered me. Of course, I could hide those pigmentation spots under a thick layer of foundation, but I don’t want that. I’d rather have beautiful, healthy skin than have to hide it under a layer of makeup.”

The challenge

“I have tried almost every known “normal” skincare product that would help against pigmentation or hyperpigmentation, but unfortunately without really good results. No matter what I tried, nothing would work. And unfortunately, it also didn’t help (anymore) to protect my skin properly from the sun, the damage was already done. Of course, I have always protected my skin well, after all, I don’t want more pigmentation.”

In the end, she uses a prescription for hydroquinone 4% cream from her pharmacist, Simon Smith. She had been using this prescription for some time and told Simon that she had recently suffered from dehydrated skin, which was vulnerable to winter conditions. Hydroquinone is an API that is susceptible to oxidation. For Sabine’s dehydrated skin, a solution containing hydroquinone in a single formulation would be preferable.

The solution

Her pharmacist helped her out, by compounding with the unique Fagron trademark vehicle from Fagron Advanced Derma Patient. Simon Smith compounded hydroquinone 4% in Nourivan™ Antiox and was able to deliver an elegant single treatment skincare solution to Sabine. “I am pleased that I now only have to apply one product, which is much more convenient, and that there has been a marked improvement in my skin condition. My hyperpigmentation is much less present now. My skin feels more even and is much less dehydrated.”


  • hydroquinone 4% compounded in Nourivan™ Antiox

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