Jane is experiencing hormonal fluctuations

Case study | 25 May 2024

Hormonal imbalance

Hormonal imbalance occurs when there is too much or too little of a hormone in the bloodstream. Because of their essential role in the body, even small hormonal imbalances can cause symptoms and complaints throughout the body. Hormones are chemicals produced by glands in the endocrine system. Hormones are released into the blood and flow through the body. They are like the messengers delivered to the blood. They give messages or signals to the tissues and organs telling them what to do and when to do it. Hormones regulate many body processes, such as metabolism and appetite, heart rate, sleep cycle, mood and stress level, body temperature, etc. Therefore, a hormonal imbalance can wreak havoc on a wide range of body functions. Resolving or treating a hormonal imbalance focuses on the underlying cause. Sometimes self-care is sufficient.

Jane visits her OB/GYN discouraged

Jane (age 51) visits her OB/GYN discouraged. “I try to live a healthy lifestyle. Yet I feel incessantly tired and suffer from moodiness, weight gain, lack of libido, memory loss, difficulty concentrating, depression, hair loss, and premature aging.” After a few tests, her OB/GYN determines that there is a hormonal imbalance. Every woman experiences hormonal fluctuations at some point in her life. It is not pleasant to suffer from hot flashes, night sweats during menopause, or painful ovulation. “I don’t feel very happy and my symptoms really bother me.”

The challenge

Jane was treated with antidepressants without success. “They just made me feel worse. The antidepressants caused me headaches, nausea, and I also felt blurry, was incredibly tired, and had nasty gastrointestinal problems.” This did subside somewhat, but the effects were anything but progressive. Her healthy lifestyle was not paying off either. “I started eating regularly, avoiding soy, eating flaxseed and cabbage, and started exercising regularly. But all without success.”

The solution

Her doctor chooses a bio-identical hormone therapy. He prescribed a Fagron A Tri-Est in Pentravan® transdermal cream to Jane. By using Pentravan®, the pharmacist can easily formulate a vanishing transdermal cream that leaves no sticky residue. This allows Jane to administer her hormones quickly and easily. “Soon after using the Tri-Est in Pentravan® cream, I felt more energized and revitalized. My weight is now more stable, I no longer lose hair, and my sex life has improved significantly.”


  • Estradiol 0.025%, estriol 0.2% and estrone 0.025% in Pentravan®

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