Pigmerise™ is a natural phytocomplex obtained from the black pepper fruits used as a repigmentation treatment for hypopigmentation disorders such as vitiligo.

What is hypopigmentation? 

Melanin is a term for a group of natural pigments responsible for the pigmentation of skin and hair. The melanin pigments are produced in a specialized group of cells known as melanocytes, located at the basal layer at border between the dermis and epidermis. When these cells don’t make enough melanin, the skin can lighten and result in a condition called hypopigmentation. Hypopigmentation is a condition in which areas of the skin are lighter than normal. These areas can occur in specific spots, such as face and limbs, or they can occur across the whole body. It can be caused by injury, inflammation, skin infection, certain medical conditions, or certain medicines. An example of hypopigmentation is vitiligo, an acquired chronic pigmentation disorder that is characterized by white patches of skin that are often symmetrical and usually increase in size and number over time. It affects 0.5% to 1% of population worldwide, it does not affect physical health, but can have a strong impact on self-esteem. 

Product brochure

Piperine and skin repigmentation

Topical treatment with piperine, a natural extract obtained from the black pepper fruit, can be a promising innovative treatment of hypopigmentation in the stable phase. The mechanism of action and beneficial properties of piperine in skin repigmentation have been extensively studied for years. Topical application of piperine, isolated or in combination with UVR therapy, has proven to be an effective repigmentation treatment for hypopigmentation disorders such as vitiligo. Fagron’s R&D team developed Pigmerise™, a natural phytocomplex obtained from the black pepper fruits (Piper nigrum L.) that contains alkaloids and volatile oils for a synergistic effect. Several case studies with Pigmerise™ in Fitalite™ applied topically in combination with UVR therapy showed promising results for the treatment of bilateral vitiligo.

Key facts and figures

of patients show improvement in repigmentation
available at Fagron
phytocomplex obtained from the black pepper fruits


Pigmerise™ is a natural extract obtained from the black pepper fruit (Piper nigrum L.). It is a natural phytocomplex with alkaloids and volatile oils in an oleoresin. Pigmerise™ contains a high concentration of alkaloids of Piper nigrum L. It stimulates melanocyte proliferation and dendrite formation, resulting in skin repigmentation. Pigmerise™ is indicated for the treatment of a wide range of hypopigmentation disorders such as vitiligo and idiopathic guttate hypomelanosis. Pigmerise™ is a water-soluble oleoresin that can be easily compounded in Fitalite™. There is no need for the use of alcohol in the compounding process, therefore reducing the risk of skin irritation. The compounded preparation of Pigmerise™ in Fitalite™ offers an innovative and safe alternative for the treatment of hypopigmentation disorders. The formulation can be used on sensitive skin, in difficult to treat areas, and in children.

  • Safe and effective with or without UVB therapy
  • Can be used in children, sensitive skin, and difficult areas
  • Exclusively available at Fagron
See Pigmerise™ formulations