The objective was to investigate the effect of low doses of vaginal gestrinone with oral Pinus pinaster extract and resveratrol on endometriosis-related pain. Results showed that concomitant use of Mirena® with low doses of vaginal gestrinone in association with oral antioxidants is an effective treatment for deep endometriosis-related pain.

The study purposed to evaluate the trans-resveratrol permeation efficacy through the vaginal route. The permeation experiments showed that resveratrol, in the formulation used, was not successfully delivered to the bloodstream – it was actually retained within the vaginal mucosa, which suggests a local use rather a systemic one.

The stability of 10 active pharmaceutical ingredients was studied in SyrSpend SF PH4 or SyrSpend SF Alka. This study demonstrated the stability of a wide range of frequently used active pharmaceutical ingredients, tested in SyrSpend SF PH4 and SyrSpend SF Alka at different storage conditions.

An analytical method by HPLC was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The results suggest that the emulsion studied is a potential vehicle for trans-resveratrol administration by transdermal route.

RP-HPLC based analytical method for use in both quality control of green tea in a semisolid formulation and for in vitro drug release assays was developed and validated. The data showed that EGCG will be able to exert its systemic activity when delivered though the transdermal formulation.

In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. The emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids

The purpose of this study was to evaluate the permeation potential of Pentravan. According to the results, human female sexual hormones incorporated in the oil-in-water vanishing cream base and applied topically are expected to exert their biological activities systemically with good efficacy due to their satisfactory permeation through human skin.

The aim of this study was to establish the profile of resveratrol permeability into and across human skin. The results show that a person using a 1g dose containing 20 mg of resveratrol will (theoretically) have 12.53 mg of it liberated into his bloodstream, gradually and continuously for 24 h.

The objective of this study was to determine the stability of rifampin (25mg/ml) in SyrSpend SF. Based on data collected, the beyond-use date of the preparation is at least 60 days when refrigerated or stored at room temperature and protected from light.

The objective of this study was to determine the stability of midazolam in SyrSpend SF and SyrSpend SF Cherry suspending agents. Based on the data collected, the beyond-use date of these preparations is at least 58 days when protected from light at both refrigerated and room temperature storage conditions.