Pentravan | 2018 The Effects of Vaginal Gestrinone with Histone Deacetylase Inhibitors on Endometriosis-Related Pain and Endometrial Proliferation – A Short Study Maia H jr, Haddad C, Saback W jr Journal of Clinical Case Studies, 3(1). The objective was to investigate the effects of vaginal valproic acid or resveratrol with vitamin D3 in Pentravan®, on deep endometriosis-associated pain in patients treated with gestrinone. They potentiated the effects of gestrinone in the first month of treatment; however, this difference disappeared in the subsequent months. Read article
Pentravan | 2018 Treatment of endometriosis and leiomyoma with the association of miodesin and gestrinone in Pentravan through the vaginal route Maia H, Saback W, Haddad C, Sitya PR Journal of Clinical Review and Case Reports, 3(7), 1-5. The effects of Myodesin™ on uterine volume and pain scores were investigated in a group of patients with leiomyoma and endometriosis. Miodesin treatment increased the efficacy of Gestrinone to reduce pelvic pain and uterine volume in patients with endometriosis and leiomyoma. Read article
TrichoConcept | 2018 Resveratrol, Blueberry, Cranberry and Raspberry Exhibit Protection Effect to Photodamaged Hair de Souza Gomes J, Silva Rita M, da Cunha Altomare JM, Raposo NRB, Brandao MAF, Polonini HC Journal of Dermatology Research and Therapy, 4(2), 061. In this study, conditioners using blueberry, raspberry, cranberry and resveratrol in TrichoCond® were developed. Two out of the seven presented significative sun protection. Three samples of treated hair presented suitable results in maintenance of the cystine content after sun exposure. Conditioners containing resveratrol showed better protection against solar radiation. Read article
Syrspend SF | 2017 Stability of Acetazolamide, Baclofen, Dipyridamole, Mebevarine Hydrochloride, Propylthiouracil, Quinidine Sulfate, and Topiramate Oral Suspensions in SyrSpend® SF PH4 Ferreira AO, Polonini HC, Loures da Silva S, Buzinari Aglio NC, Abreu J, Brandao MAF International Journal of Pharmaceutical Compounding, 21(4), 339-346. The objective of this study was to evaluate the stability of 7 commonly used APIs ingredients compounded in SyrSpend SF PH4. The beyond-use date of the final products (active pharmaceutical ingredient + vehicle) was at least 90 days for all suspensions with regard to both temperatures. Read article
StripMax | 2017 Technological Device for Manufacturing Transdermal Films: Possible Applications to the Individualized Treatment for Erectile Dysfunction Raposo FJ, Polonini HC, Ferreira AO, Raposo NRB, Brandao MAF AAPS PharmSciTech, 18(7), 2824-2831. This study aimed to develop a device to produce transdermal patches in compounding pharmacies. Tadalafil could permeate to the viable epidermis and dermis (5.7%). The created device produced homogeneous patches of tadalafil, showing feasibility in individualized therapy for the treatment of erectile dysfunction. Read article
OrPhyllo | 2017 Orodispersible Films for Compounding Pharmacies Ferreira AO, Brandao MAF, Raposo FJ, Polonini HC, Raposo NRB International Journal of Pharmaceutical Compounding, 21(6), 454-461. This article aims to explore some of the basics on orodispersible film and the main possible preparations to be developed in compounding pharmacies worldwide. Read article
Syrspend SF | 2017 Suspensions as a Valuable Alternative to Extemporaneous Compounded Capsules Dijkers E, Nanhekhan V, Thorissen A, Polonini HC International Journal of Pharmaceutical Compounding, 21(2), 171-175. The objective of this study was to determine the variation in content of 74 different APIs and compare it with existing literature on the content uniformity of extemporaneous prepared capsules. Compounded oral liquids show little variation, appearing to be a suitable alternative when compounding individualized medications for patients. Read article
Syrspend SF | 2017 Stability of Alprazolam, Atropine Sulfate, Glutamine, Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride, Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF PH4 Oral Suspensions Ferreira AO, Polonini HC, Loures da Silva S, Cerqueira de Melo VA, de Andrade L, Brandao MAF International Journal of Pharmaceutical Compounding, 21(3), 255-263. The objective of this study was to evaluate the stability of 10 commonly used APIs compounded in oral suspensions using SyrSpend SF PH4. The beyond-use date of the final products (APIs + vehicle) was at least 90 days for all suspensions with regard to both temperatures. Read article
Syrspend SF | 2017 Limited Influence of Excipients in Extemporaneous Compounded Suspensions Dijkers E, Nanhekhan V, Thorissen A, Marro D, Uriel M Hospital Pharmacy, 52(6), 428-432. The objective of this study was to assess oral suspensions with SyrSpend SF based on tablets or capsules as a suitable alternative for using raw APIs. Based on this study, a wide range of excipients do not seem to impact the beyond-use date of different APIs compounded in SyrSpend SF. Read article
Pentravan | 2017 Detection of Enrofloxacin After Single-Dose Percutaneous Administration in Python regius, Boa constrictor imperator, and Acrantophis dumerili Ducrotte-Tassel A, Kirilov P, Salvi JP, Czyz I, Dore V, Marignac G, Pignon CP, Boulieu R, Perrot S Journal of Exotic Pet Medicine, 26(4), 263-269. In this study, the blood concentrations of enrofloxacin administered transdermally to 3 different reptilian species at 50 mg/kg were determined. Although the values were unquantifiable, this study confirms the absorption of enrofloxacin. Read article