The current study investigates the effect of intranasal administration of essential oils obtained from lavender, French lavender, and fennel (Pinetonina™), on chronic stress. Daily intranasal use of Pinetonina™ before sleep showed a significant reduction of salivary cortisol levels and improved quality of sleep.

This research investigated the effects of Miodesin™ on acute and chronic inflammatory processes as well as possible epigenetic involvement. Miodesin™ inhibited the release of LPS-induced cytokines and chemokines, and the expression of the transcription factor, inflammatory enzymes, and chemokines. In addition, Miodesin™ did not induce changes in DNA methylation.

The study evaluated the efficacy of an automated robotic cleaning device (RVC1) for compounding pharmacies and other primary healthcare establishments. RVC1 showed the necessary microbiological and chemical efficacy to be used in the cleaning routine of compounding pharmacies, both in a single-step cleaning or in a double-step cleaning.

This study investigated the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition, defined in terms of two outcomes: percentage of lean mass and percentage of fat mass. There was a statistically significant evidence that the treatment may increase lean mass and reduce fat mass.

In this paper, the use of an ointment mill in final steps of compounding semisolid dosage forms is evaluated, showing better homogeneity when assessing content uniformity of progesterone 5%, estradiol 0.1%, and estriol 0.4% creams. Finally, the proposed cleaning procedure decreased the presence of compounded preparation to a “none-detection” level.

The purpose of this study was to evaluate the transmucosal permeation of progesterone and testosterone using Pentravan as its vehicle for vaginal delivery. The permeation studies revealed that testosterone formulated with Pentravan is potentially effective in reaching the bloodstream and acts locally, whereas progesterone was mostly retained in the mucosa.

The main objective of the study was to assess whether SiliciuMax (liquid) can deliver silicon to the epidermis and dermis, when applied topically in a cream. Evidence shows that SiliciuMax applied topically can deliver silicon to the skin in biorelevant levels for cosmetic purposes.

The use of Pentravan to deliver metformin hydrochloride through the skin was evaluated. A 46.7% permeation percentage was found, with a drug flux of 3.91 µg cm/-2/h-1 and a lag time of 0.51 h, suggesting the transdermal route can be an option for patients searching for diverse clinical effects.

The main objective of the study was to evaluate the ex vivo permeation of a transdermal formulation containing desmopressin, using Pentravan®. The formulation developed was able to promote transdermal absorption of desmopressin, showing a permeation percentage of 21.5%. Thus, sufficient amounts of desmopressin were delivered to achieve a systemic effect.

The study aimed to study the effect of caloric restriction (CR) and resveratrol (Rv) in wound repair. Results show that the CR and Rv group had enhanced numbers of blood vessels, VEGF, fibroblast, birefringent collagen fiber areas in the lesion and may modulate angiogenesis, fibroplasia, and collagenesis.