This ex vivo study aimed to characterize the percutaneous absorption pharmacokinetics of tramadol 100mg/ml in Pentravan through feline inner pinna skin. The tramadol formulation was stable for three months at room temperature. Tramadol penetrated through the feline inner pinna skin, but considerable intra- and inter-individual variability in kinetics was observed.

This study assessed the beyond-use date (BUD) of seven APIs for topical use for alopecia in TrichoWash, TrichoCream, TrichoCond, and TrichoSol: All formulations presented a BUD of 6 months, except for latanoprost in TrichoCream and latanoprost in combination with minoxidil and finasteride in TrichoSol (BUD 3 months).

In this study, the beyond-use date of formulations containing estradiol, estriol, estrone, progesterone, and testosterone in combination, compounded with Fitalite, Versatile, and HRT Supreme Cream base was evaluated. A beyond-use date of 180 days was observed for all vehicles stored both at refrigerated and at room temperature.

In this article, theoretical scientific support for Yuliv Collagen Drink and its benefits on the skin is presented. Literature shows that its ingredients have the potential to improve hydration, and dermis collagen density. Other benefits observed include oxidative stress protection, immune system support, and reduction of fatigue, and skin inflammation.

The study evaluated the efficacy of a new 3-axis mixer device. Three formulations were compounded, a total of 540 individual tests were performed, and two alternative methods were compared. The 3-axis device provided homogeneous mixtures and finished capsules with adequate content uniformity, and proved superior to classical mixing methods.

This study demonstrates the proteomic analysis, nutritional composition, and safety profile of Imuno TF®, a complex set of 163 different peptides, 10 vitamins, and 11 minerals. The chemical composition showed low fat and sugar content and no saturated fatty acids. No mutagenic effect was observed.

In this paper, Cleoderm is presented as a ready-to-use vehicle for the compounding of acne treatments and products for oily skin. Evidence shows multiple positive roles of Cleoderm including a decrease in sebum production, lipid peroxidation, and reactive oxygen species, inhibition of Cutibacterium acnes proliferation, and control of inflammation.

The effect of Pentravan® on skin permeability was examined for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with new L-valine alkyl esters. The resulting Pentravan-based creams with ibuprofen in the form of an ionic pair represent a potential alternative to other forms of the drug-containing analgesics administered transdermally.

In this work, the compatibility of Pentravan and three active pharmaceutical ingredients was determined: gestrinone, a steroidal substance for vaginal use, and nimesulide and piroxicam, two nonsteroidal anti-inflammatory drugs used for topical and vaginal application. This article shows an excellent beyond-use date of 180 days when stored at room temperature.

In this study, the stability in Pentravan®/Plus of danazol, metformin HCl, and resveratrol, as well as metformin HCl, resveratrol, and Vitamin D3 in combinations at bracketed high/low concentrations, were evaluated over a period of 6 months. All formulations presented a beyond-use date of at least 6 months.