SyrSpend® SF – Scientific evidence for another 10 APIs

Tue, 04/05/2016
SyrSpend® SF – Scientific evidence for another 10 APIs

SyrSpend® SF is an internationally available vehicle which is a GMP produced, ready-to-use, taste-masking oral liquid with strong scientific evidence. In the study published in the April edition of Die Pharmazie, the physical and chemical stability of another 10 APIs was studied in SyrSpend® SF PH4 liquid1:

  • Cholecalciferol
  • Haloperidol
  • Imipramine hydrochloride
  • Levodopa/carbidopa
  • Lorazepam
  • Minocycline hydrochloride
  • Tacrolimus monohydrate
  • Terbinafine
  • Tramadol hydrochloride
  • Valsartan

The beyond-use date for almost all studied SyrSpend® SF suspensions is 90 days for refrigerated conditions (2-8°C) and room temperature (20-25°C). Minocycline hydrochloride has a beyond-use date of 60 days at both storage temperatures, levodopa/carbidopa and lorazepam has respectively 30 and 60 days stability at room temperature.

An overview of all available formulations with SyrSpend® SF can be found in our free online formulations database, Compounding Matters.


1Polonini HC, Silva SL, Cunha CN, Brandão MAF, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend® SF PH4 oral suspensions. Die Pharmazie, 71: 185-191 (April 2016).